Officers recovered ‘suspicious items’ from a property on Coronation Avenue following a warrant executed at 12.11pm this afternoon.
The Army’s Explosive Ordinance Disposal team are currently at the scene.
A spokesperson from South Yorkshire Police said: "A 100m cordon is in place and around 50 homes have been evacuated.
“Barnsley Council has arranged an evacuation centre for those affected. Social distancing will be facilitated.
“Coronation Avenue and Queens Road are both closed.
“An investigation is underway and a 40-year-old man has been arrested in connection with the incident.
“Members of the public are urged to stay away from the scene to keep the area clear for the police and our emergency services colleagues to carry out our work.
“Further updates will be issued when available.”
This is an ongoing incident and updates will be provided as soon as possible.