The plants - at a house in Wombwell - were in varying staged of production from saplings through to mature plants that were ready for harvesting.
A ‘substantial amount’ of cannabis that had already been harvested was seized - as well as equipment from the property.
One male was arrested at the address.
A spokesperson for South Yorkshire Police said: “This action is a direct result from excellent information from the the community, and has resulted in a significant and well-established cannabis cultivation set up being dismantled.”