Barnsley Hospital is to trial a drug used in the Gulf War to see if it can stem bleeding in cases of brain haemorrhages and stomach ulcers.
The trial, which is about the start in the next few weeks is of a drug called tranexamic acid and was used to clot the blood flow from solders' wounds in the 1990-91 conflict.
Julian Humphrey and James Griffiths, consultants in the emergency department, said previous testing in soldiers had shown better results than in those who didn't.
Dr Humphrey added: "Now this drug is being looked at in other forms of bleeding to see if it can help patients.
"Patients who come in with brain haemorrhages and bleeding from inside their stomach will be compared with patients who didn't receive the drug to see which one gave the better outcome."
Clinical trials have been taking place at Barnsley Hospital since about 2004 when up to 300 people took part in a study about heart failure and chest pains.
Ongoing studies include patient experience in the intensive care unit, treatment for severe infections and an assessment to help spot children's illnesses earlier.
Dr Humphrey said: "If you come to the emergency department at Barnsley Hospital there is a chance you will be asked to take part, it's all about trying to check which is the best treatment."
More than 1,000 people across Barnsley had taken part in trials over the last five or six years and there are about 120 trials taking place at the moment.
