BARNSLEY left it late and won the game in bizarre fashion thanks to Sam Cosgrove’s first goal of the season.
The Reds put the away side under pressure in the second half but finally broke the deadlock in the 91st minute.
Head coach Neill Collins named an unchanged starting 11 for the game, with Corey O’Keeffe replacing fellow wing-back Owen Dodgson on the bench.
Ex-Red Josh Scowen captained Matt Bloomfield’s side - he left Barnsley to join Queen’s Park Rangers in 2017.
Barnsley controlled the opening ten minutes of the game, with Nicky Cadden having Collins’ side first effort on goal.
But his effort was wide on Max Stryjek in the Wycombe goal.
Luca Connell started the game brilliantly, winning balls in midfield and spraying balls left and right - and there’s no doubt he’s now the focal point of Barnsley’s midfield.
But the first half transcended into a scrappy and dull game with very little happening.
Neither side had any clear-cut opportunities and the Reds were particularly sloppy on the ball.
Wycombe had half a chance to break just before half time but Killip collected well, before the referee blew his whistle for the break.
The second half began much like the first ended, with both sides unable to keep a hold of the ball and making silly mistakes.
There were strong shouts from the bench for a red card in the 59th minute when Phillips went in late on de Givigney, but the referee only brandished a yellow card.
Substitute Sam Cosgrove should have scored just minutes after coming off the bench, but he somehow shot wide from five yards out following a great McAtee cross.
The Reds then had two great chances to take the lead.
First Williams headed straight at the ‘keeper who pushed it be hind for a corner, before the resulting set piece found de Givigney whose header was so close to the back of the net.
For all the pressure Barnsley were putting Wycombe under they couldn’t find a goal - and it was almost the away side who opened the scoring in the 79th minute.
Lyle Taylor found space in the box and unleashed a powerful effort, but de Givigney did brilliantly to block the shot and divert it wide of the goal.
The Reds took the lead in bizarre fashion in added time as the Wycombe ‘keeper spilled the ball and Cosgrove tapped into an empty net.
Harry Boyes was sent off for protesting the goal.
Tempers continues to flare in the final stages but the Reds held out for a 1-0 win.