Last Monday the venue opened on Fall Bank Industrial Estate, Dodworth.
It will sell clothing, furniture, homeware and DVDs and all proceeds will go towards the hospice to help fill the £2,300-a-day funding gap left by the pandemic.
The hub was announced when the six Barnsley Hospice shops were forced to close in October.
Long-time volunteer, Judy Holling, officially opened the store and said: “The hospice means so much to me and I like to do all I can to support it. Hospice care is very important for so many families who need it and I really hope people will come to our new retail hub and support us.”
The hub will be open Monday to Saturday, 9am to 5pm.